# 22 LR Semi Automatic Handguns - Guns For Sale

Explore .22 LR semi-automatic handguns built for rimfire range time, target practice, plinking, and low-recoil training. This selection includes compact pistols like the Armalite ISSC M22 and Beretta 21A Bobcat, plus full-size target and 1911-style options such as the Ruger 22/45, Ruger Mark III, Mauser 1911, and Chiappa 1911-22.

Browse models with practical barrel lengths, familiar controls, black, stainless, OD green, and FDE finishes, and range-ready configurations like the FN 502 Tactical and Standard Manufacturing Jackhammer. These .22 LR semi-auto pistols fit shoppers looking for a lighter-shooting handgun for practice sessions, skill building, or classic rimfire fun.

## Featured Firearms (106 total)

| Product | Caliber | Price |
|---------|---------|-------|
| [Ruger Mark III .22 LR 5.5in Stainless](https://gunsnation.com/p/ruger-mark-iii-22-lr-5-5in-stainless/UCCy77qPG) | .22 LR | - |
| [Ruger Mark IV 22/45 Tactical .22 LR 3in ODG](https://gunsnation.com/p/ruger-mark-iv-22-45-tactical-22-lr-3in-odg/UCCy796eo) | .22 LR | - |
| [Taurus TX-22 .22 LR 4.1in Cyan](https://gunsnation.com/p/taurus-tx-22-22-lr-4-1in-cyan/UCClj85Ky) | .22 LR | - |
| [Ruger Mark IV 22/45 .22 LR 3in Black](https://gunsnation.com/p/ruger-mark-iv-22-45-22-lr-3in-black/UCCy796eK) | .22 LR | - |
| [Kel-Tec P17 .22 LR 3.8in Green/Black](https://gunsnation.com/p/kel-tec-p17-22-lr-3-8in-green-black/UCBHUno8o) | .22 LR | - |
| [Kel-Tec P17 .22 LR 3.8in Tan](https://gunsnation.com/p/kel-tec-p17-22-lr-3-8in-tan/UCBHUno8h) | .22 LR | - |
| [Taurus TX22 Gen 2 .22 LR 4.60in Black](https://gunsnation.com/p/taurus-tx22-gen-2-22-lr-4-60in-black/UCClj88DC) | .22 LR | - |
| [Taurus TX22 Gen 2 T.O.R.O. .22 LR 4.6in Black/ODG](https://gunsnation.com/p/taurus-tx22-gen-2-t-o-r-o-22-lr-4-6in-black-odg/UCClj88CD) | .22 LR | - |
| [Taurus TX22 Gen 2 TORO .22 LR FDE/Black](https://gunsnation.com/p/taurus-tx22-gen-2-toro-22-lr-fde-black/UCClj88CK) | .22 LR | - |
| [Ruger Mark IV .22 LR 4.4in Black](https://gunsnation.com/p/ruger-mark-iv-22-lr-4-4in-black/UCCy79GUB) | .22 LR | - |
| [CMMG Banshee Mk4 .22 LR 9in Armor Black](https://gunsnation.com/p/cmmg-banshee-mk4-22-lr-9in-armor-black/UCEGJR3pf) | .22 LR | - |
| [Browning Buck Mark .22 LR 5.5in Black](https://gunsnation.com/p/browning-buck-mark-22-lr-5-5in-black/UC49lXNT8) | .22 LR | - |
| [Hammerli Arms Forge H1 Trump 2024 .22 LR 5in Black](https://gunsnation.com/p/hammerli-arms-forge-h1-trump-2024-22-lr-5in-black/UCC75eyxl) | .22 LR | - |
| [Taurus TX22 Gen 2 .22 LR](https://gunsnation.com/p/taurus-tx22-gen-2-22-lr/UCClj88Gt) | .22 LR | - |
| [Beretta 21A Bobcat Kale Slushy .22 LR 2.9in OD Green](https://gunsnation.com/p/beretta-21a-bobcat-kale-slushy-22-lr-2-9in-od-green/UC1RzOHx2) | .22 LR | - |
| [Ruger Mark IV 22/45 Lite .22LR 4.4in Blue/Black](https://gunsnation.com/p/ruger-mark-iv-22-45-lite-22lr-4-4in-blue-black/UCCy79GTh) | .22 LR | - |
| [Ruger Mark IV 22/45 .22 LR 4.4in Black](https://gunsnation.com/p/ruger-mark-iv-22-45-22-lr-4-4in-black/UCCy796g1) | .22 LR | - |
| [Kel-Tec P17 .22 LR 3.8in OD Green](https://gunsnation.com/p/kel-tec-p17-22-lr-3-8in-od-green/UCBHUno8Q) | .22 LR | - |
| [Ruger Mark IV 22/45 250th Anniversary .22 LR 4.4in Stainless](https://gunsnation.com/p/ruger-mark-iv-22-45-250th-anniversary-22-lr-4-4in-stainless/UCCy796gn) | .22 LR | - |
| [Taurus TX22 Gen 2 T.O.R.O. .22 LR Black](https://gunsnation.com/p/taurus-tx22-gen-2-t-o-r-o-22-lr-black/UCClj88GO) | .22 LR | - |

*Showing 20 of 106 products*

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*Data from [GunsNation](https://gunsnation.com)*