.22 LR Semi-Automatic Handguns - Guns For Sale
Explore .22 LR semi-automatic handguns built for rimfire range time, target practice, plinking, and low-recoil training. This selection includes compact pistols like the Armalite ISSC M22 and Beretta 21A Bobcat, plus full-size target and 1911-style options such as the Ruger 22/45, Ruger Mark III, Mauser 1911, and Chiappa 1911-22.
Browse models with practical barrel lengths, familiar controls, black, stainless, OD green, and FDE finishes, and range-ready configurations like the FN 502 Tactical and Standard Manufacturing Jackhammer. These .22 LR semi-auto pistols fit shoppers looking for a lighter-shooting handgun for practice sessions, skill building, or classic rimfire fun.
GunsNation lists 106 .22 LR Semi-Automatic Handguns listings from multiple verified dealers. Compare them side by side to find the best price.
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- GunsNation currently aggregates 106 .22 LR Semi-Automatic Handguns listings from verified dealers, so you can compare prices in one place.
.22 LRRuger Mark III .22 LR 5.5in Stainless
.22 LRRuger Mark IV 22/45 Tactical .22 LR 3in ODG
.22 LRTaurus TX-22 .22 LR 4.1in Cyan
.22 LRRuger Mark IV 22/45 .22 LR 3in Black
.22 LRKel-Tec P17 .22 LR 3.8in Green/Black
.22 LRKel-Tec P17 .22 LR 3.8in Tan
.22 LRTaurus TX22 Gen 2 .22 LR 4.60in Black
.22 LRTaurus TX22 Gen 2 T.O.R.O. .22 LR 4.6in Black/ODG
.22 LRTaurus TX22 Gen 2 TORO .22 LR FDE/Black
.22 LRRuger Mark IV .22 LR 4.4in Black
.22 LRCMMG Banshee Mk4 .22 LR 9in Armor Black
.22 LRBrowning Buck Mark .22 LR 5.5in Black
.22 LRHammerli Arms Forge H1 Trump 2024 .22 LR 5in Black
.22 LRTaurus TX22 Gen 2 .22 LR
.22 LRBeretta 21A Bobcat Kale Slushy .22 LR 2.9in OD Green
.22 LRRuger Mark IV 22/45 Lite .22LR 4.4in Blue/Black
.22 LRRuger Mark IV 22/45 .22 LR 4.4in Black
.22 LRKel-Tec P17 .22 LR 3.8in OD Green
.22 LRRuger Mark IV 22/45 250th Anniversary .22 LR 4.4in Stainless
.22 LRTaurus TX22 Gen 2 T.O.R.O. .22 LR Black
.22 LRTaurus 22 TUC .22 LR 2.5in Stainless Blue
.22 LRBlue Line Mauser M20 .22 LR 4.7in Robins Egg Blue/Black
.22 LRTaurus TX22 .22 LR Black
.22 LRFranklin Armory F22 Binary .22 LR 8in Black
.22 LRMauser 1911 .22 LR 5in Black
.22 LRBLG Mauser TacOps .22 LR 11.8in
.22 LRRetay RXP .22 LR 4in OD Green
.22 LRTaurus 22TUC .22 LR 2.5in Purple
.22 LRRetay RXP .22 LR 4in OD Green
.22 LRRetay RXP22 .22 LR 4in Black/Grey
.22 LRVolquartsen Mini Mamba .22 LR 3in Black
.22 LRCMMG MK4 DL-44 Blaster .22 LR 5in Battle Worn Armor Black
.22 LRRuger Mark IV 22/45 Lite .22 LR 4.4in Champagne
.22 LRRuger Mark IV 22/45 Tactical .22 LR 4.4in Two-Tone
.22 LRKel-Tec P17 .22 LR 3.80in Tan/Black
.22 LRRetay RXP22 .22 LR 4in Black/FDE
.22 LRAmerican Tactical GSG-16P .22 LR 9.12in Black
.22 LRRuger Mark IV 22/45 Collector's Series .22 LR 5.5in Blued
.22 LRBlue Line Solutions Mauser HSr .22 LR 3.5in Black
.22 LRArmalite ISSC M22 .22 LR Compact Semi-Auto Pistol
.22 LRKel-Tec P17 .22 LR 3.80in Blue/Black
.22 LRRuger Mark IV Lite .22 LR 4.4in Blue
.22 LRRuger Mark IV 22/45 Lite .22 LR 4.4in Black Gray
.22 LRBlue Line Solutions Mauser TacOps PK .22 LR 5in Black
.22 LRRetay RXP .22 LR 4in OD Green & Black
.22 LRRetay RXP22 .22 LR 4in Black
.22 LRRetay RXP 22 LR 4in Gray Cerakote Black Frame
.22 LRKriss USA DMK22P .22 LR 10.5in Matte Black
Showing 1-48 of 106 firearms tagged with .22 LR Semi-Automatic Handguns
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About .22 LR Semi-Automatic Handguns
Discover the best firearms tagged with ".22 LR Semi-Automatic Handguns" at GunsNation. Browse our collection to find the perfect firearm for your needs.